Are there dendritic cells in the spleen?
The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells.
What is CD11c a marker for?
DCs bearing CD11c surface markers are potent antigen-presenting cells that reside in the skin and other tissues. DCs bridge innate and adaptive immunity, and by modulating T cell, B cell, and monocyte/macrophage function, they shape the immune response (see Figure 83-9).
Are there myeloid cells in the spleen?
The “myeloid” subset in spleen includes granulocytes, monocytes and macrophages. Granulocytes like neutrophils, eosinophils, basophils and mast cells are Ly6G+ cells mainly localised in the red pulp region, with some cells in transition through the marginal zone into red pulp [3].
Do lymphocytes express CD11c?
CD11c is definitely expressed by lymphocytes. Check out the data browser at www.immgen.org for specifics (the gene name for CD11c is itgax) – but it’s now well described that CD11c is expressed by NK cells, activated T cells, a subset of regulatory CD8+ T cells, gdT cells, and certain macrophage populations.
Do macrophages express CD11c?
It is now recognized that several non-DC myeloid populations express CD11c, including alveolar macrophages and resident (Ly6C low) monocytes and that some macrophage populations express both CD11c and MHC class II [8, 9]. Similarly, CD11b has often been used as a marker for all myeloid cell types.
What is CD103 a marker for?
CD103 is the receptor for E-cadherin, which is expressed on epithelial cells, including renal tubular epithelial cells. Independent from its role in migration of immune cells, CD103 is also a marker of T cell activation (35).
Are neutrophils CD11c positive?
Neutrophils expressing high levels of CD11c were a feature of sepsis and had a greater diagnostic accuracy for sepsis than neutrophils bearing CD64. An increased prevalence of neutrophils expressing EMR2 was associated with systemic inflammation and with organ failure.
Are platelets myeloid cells?
Myeloid progenitor cells are the precursors of red blood cells, platelets, granulocytes (polymorphonuclear leukocytes [PMNs]: neutrophils, eosinophils, and basophils), monocyte-macrophages, dendritic cells (DCs), and mast cells and osteoclasts.
Do neutrophils express CD11c?
Where are CD11c + lymphoid cells found in the body?
CD11c+ Lymphoid Tissue Dendritic Cells. Human CD11c+ LT DCs are found in the thymus, spleen, peripheral lymph nodes, and other secondary lymphoid tissues, and in small numbers in the blood. They can be divided into two major subsets: blood DC antigen (BDCA)-1+ and BDCA-3+ CD11c+ DCs.
Where are cdc2s located in the spleen?
Splenic cDC2s strategically localize in the marginal zone (MZ) bridging channel, a unique region in the spleen that extends between blood-exposed red pulp and lymphocyte-rich white pulp ( 3 ⇓ – 5 ). Upon exposure to blood-borne antigen, cDC2s become activated and move to the T-cell zone to prime CD4 + T cells.
What does CD11c stand for in immunohistology?
Immunohistology of Non-Hodgkin Lymphoma. CD11C. CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
Where are CD11c + Lt DCS found in the body?
Human CD11c + LT DCs are found in the thymus, spleen, peripheral lymph nodes, and other secondary lymphoid tissues, and in small numbers in the blood. They can be divided into two major subsets: blood DC antigen (BDCA)-1 + and BDCA-3 + CD11c + DCs.
