How is alprazolam metabolized?
Metabolism/Elimination Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major metabolites in the plasma: 4-hydroxyalprazolam and α hydroxyalprazolam. A benzophenone derived from alprazolam is also found in humans.
Is alprazolam a CYP3A4 inhibitor?
Cytochrome P450(CYP)3A4 is one of the CYP enzymes catalyzing oxidative metabolism, and involved in the metabolism of many drugs. Among benzodiazepines, alprazolam, triazolam, brotizolam and midazolam are mainly metabolished by CYP3A4, and quazepam, diazepam and flunitrazepam are partly metabolised by this enzyme.
Who manufactures alprazolam?
XANAX®, CIV (alprazolam) | Pfizer Medical Information – US.
What happens if you take a lot of alprazolam?
A Xanax overdose may have mental and physical symptoms like anxiety, loss of coordination and extreme sedation. Taking too much Xanax severely depresses the central nervous system, and can lead to a coma or death. Overdose from benzodiazepine drugs has been on the rise for the better part of two decades.
Is Alprazolam bad for your kidneys?
Xanax or alprazolam should not have any effect on the kidneys, even if taken for 30 years.
Is ALPRAZolam bad for your liver?
Some people experience elevated liver enzymes when using Xanax long-term. This may be a sign of liver inflammation, a condition that can lead to or result from damage to liver tissue. Liver damage is even more likely if Xanax is combined with alcohol.
What are the contraindications of alprazolam?
Who should not take ALPRAZOLAM?
- overweight.
- suicidal thoughts.
- alcohol intoxication.
- drug abuse.
- depression.
- wide-angle glaucoma.
- closed angle glaucoma.
- decreased lung function.
Why is Xanax no longer available?
The Food and Drug Administration has announced a nationwide recall of a batch of alprazolam, a generic version of Xanax, because of potential contamination. The manufacturer, Mylan Pharmaceuticals, said Friday that the voluntary recall was because of the possible presence of a foreign substance.
Is there a recall on alprazolam?
October 28, 2019 — One lot of alprazolam, brand name Xanax, is being recalled by Mylan Pharmaceuticals Inc. due to potential contamination that poses a risk of infection. The recall is for lot number 8082708 of alprazolam tablets, USP C-IV 0.5 mg packaged in bottles of 500, with an expiry date of September 2020.
What is the therapeutic level of Xanax?
Depending on the response, the dosage may be increased at intervals of every 3 to 4 days in increments of no more than 1 mg per day. Controlled trials of XANAX in the treatment of panic disorder included dosages in the range of 1 mg to 10 mg daily. The mean dosage was approximately 5 mg to 6 mg daily.
Which drug is a good substitute for alprazolam?
Some of the Good Substitutes for Alprazolam are given below: Ancolam Tablet. P Kalm Tablet. Zolam Tablet. Alprax Tablet. Alzolam Tablet. Alprax Tablet. Eldezolam Tablet.
What is the best use of alprazolam?
Alprazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It affects chemicals in the brain that may be unbalanced in people with anxiety. Alprazolam is used to treat anxiety disorders, panic disorders, and anxiety caused by depression. Alprazolam may also be used for purposes not listed in this medication guide.
What are the risks of taking Xanax?
As with any prescription drug, Xanax comes with a risk of adverse side effects that is increased with excessive use and abuse. Side effects of prolonged Xanax use may include: dry mouth. blurred vision. nausea or vomiting. constipation. weight and appetite changes. dizziness.
When should Xanax be taken?
In the case of social anxiety disorder, Xanax is more commonly prescribed for cognitive symptoms such as worrying about performance or the judgment of others. In this case, Xanax can be taken about an hour before a performance event.
