What is the proper reconstitution of CroFab?
Each vial of CROFAB should be reconstituted with 18 mL of 0.9% Saline (diluent not included) and mixed by continuous manual inversion until no solid material is visible in the vial. Do not shake.
How long does it take to reconstitute CroFab?
manual inversion until no solid material is visible in the vial. Do not shake. Further dilute the contents of all of the reconstituted vials to a total volume of 250 mL with 0.9% Sodium Chloride and mix by gently swirling. Use the reconstituted and diluted product within 4 hours.
How many times can you get CroFab?
Once initial control has been achieved, additional 2-vial doses of CROFAB every 6 hours for up to 18 hours (3 doses) are recommended. Optimal dosing following the 18-hour scheduled dose of CROFAB has not been determined.
How much does a vial of CroFab cost?
Having the market all to itself, CroFab has quadrupled in price since its launch, according to data from the health technology company Connecture. Today, the list price for wholesalers for the medicine is $3,198 a vial, and the recommended starting dose is four to six vials.
Is CroFab an antivenom?
CroFab® is the only antivenom derived exclusively from US snakes to treat all North American pit viper envenomations in adult and pediatric patients. 98% of venomous snakebites in the United States are from the North American pit viper.
What are the 3 drugs that are always recommended to have by the bed side when administering CroFab or any antivenom?
Physicians should be present for antivenin administration, and epinephrine and antihistamine should be at the bedside.
How do you administer CroFab?
Administering CroFab® to Achieve Control1: Mix 4-6 vials‡ of CroFab® in 250 mL normal saline (0.9% sodium chloride) Infuse over 60 minutes, proceeding slowly over the first 10 minutes at a 25- to 50-mL/hour rate with careful observation for any allergic reaction.
How long do you have after a copperhead bite?
The nurse can share that with copperhead bites the usual prognosis is 8 days of pain, 11 days of extremity edema, and 14 days of missed work and a full recovery is expected.
Which snake has no anti-venom?
This includes various types of cobras, kraits, saw-scaled vipers, sea snakes, and pit vipers for which there are no commercially available anti-venom.
What is the most expensive antivenom?
Priced at $39 million per gallon, deathstalker scorpion venom easily ranks as the world’s most expensive strain — and with good reason: The deathstalker’s sting hurts 100 times more than that of a bee, putting the milker at high risk.
Which is correct antivenin or antivenom?
Antivenom (often spelled “antivenin”) is an antibody product that can disable a particular venom’s toxins. If injected quickly after a bite or sting, the antibodies in antivenom neutralize the venom, potentially saving the victim’s life or limb.
Are copperhead bites fatal to dogs?
Copperhead bites are common, but like all snake bites, they generally occur because the dog attacked them, not the other way around. These bites are generally not fatal, but can cause severe pain, swelling and local tissue damage.
What is the reconstitution process for CroFab?
Watch a video on the reconstitution process for CroFab ®. 1. CroFab® [prescribing Information]. BTG International Inc; January 2018. 2. Lavonas EJ, Ruha AM, Banner W, et al. Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop.
How to administer CroFab in an ICU setting?
Administering CroFab ® to Achieve Control 1: Establish IV access and give IV fluids. Initiate first dose of CroFab ® in ED or ICU. Mix 4-6 vials † of CroFab ® in 250 mL normal saline (0.9% sodium chloride) Infuse over 60 minutes, proceeding slowly over the first 10 minutes at a 25- to 50-mL/hour
How many vials of CroFab should I take?
Based on clinical experience with CROFAB, the recommended initial dose is 4 to 6 vials; however, the starting dose may vary from a minimum of 4 vials to a maximum of 12 vials based on clinical judgment and severity of envenomation [3].
Are there any side effects to taking CroFab?
Incidence of immediate hypersensitivity reaction and serum sickness following administration of crotalidae polyvalent immune Fab antivenom: a meta-analysis. Acad Emerg Med. 2012;19 (2):121-131.
