What are the symptoms of hepatotoxicity?
Symptoms
- Yellowing of the skin and whites of the eyes (jaundice)
- Itching.
- Abdominal pain in the upper right portion of the abdomen.
- Fatigue.
- Loss of appetite.
- Nausea and vomiting.
- Rash.
- Fever.
How does valproate cause hepatotoxicity?
The mechanism of valproate hepatotoxicity is thought to be due to mitochondrial toxicity, perhaps from inhibition of beta oxidation and subsequent loss of mitochondrial function. Valproate is extensively metabolized by the liver and excreted in urine.
Can phenytoin cause liver damage?
Phenytoin is an anticonvulsant that in rare cases can cause acute idiosyncratic drug-induced liver disease that can be severe or even fatal. The liver injury caused by phenytoin appears to be due to a hypersensitivity reaction and resembles cases of immunoallergic hepatotoxicity.
Does epilim affect the liver?
Medicines used in the treatment of epilepsy, including Epilim may have adverse effects on the liver and the kidneys.
Is hepatotoxicity serious?
In some cases, hepatotoxicity can be life-threatening. HIV medicines that are causing serious, life-threatening hepatotoxicity must be stopped immediately.
Is valproic acid Safe?
It’s unusual to have serious side effects after taking valproic acid. Tell a doctor straight away if you have: thoughts of harming or killing yourself – a small number of people taking valproic acid have had suicidal thoughts. yellowing of your skin or whites of your eyes – these may be warning signs of liver problems.
Can valproic acid damage the liver?
Valproic acid may cause serious or life-threatening damage to the liver that is most likely to occur within the first 6 months of therapy.
What are the long term side effects of phenytoin?
Long-term use of phenytoin also has been found to cause weakening of the bones. Bone disease is even more likely if a combination of seizure medicines is used….The most common ones affect appearance:
- overgrowth of the gums.
- excessive hair on the face or body.
- acne.
- coarseness of facial features.
What happens when you stop taking Epilim?
What will happen when I come off it? Do not stop taking sodium valproate suddenly, unless your doctor tells you to. You’re unlikely to get any extra symptoms when you stop taking this medicine. However, if you’re taking sodium valproate for epilepsy, it’s possible that you’ll get seizures again once you stop taking it.
Does epilim cause aggression?
The authors point out that as side effects of sodium valproate can include aggression, hyperactivity and behavioural disturbances, then if it is prescribed for the treatment of bipolar disorder with co-occurring behavioural disturbances, it is possible that the medication may make these behaviours worse.
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