What is the mechanism of action of trimetazidine?
Mechanism of action Trimetazidine inhibits beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl-CoA thiolase, which enhances glucose oxidation. In an ischaemic cell, energy obtained during glucose oxidation requires less oxygen consumption than in the beta-oxidation process.
Is trimetazidine a beta blocker?
Despite efficacy being equivalent to that of beta-blockers and calcium antagonists, trimetazidine does not depress cardiac function and, correspondingly, is not contraindicated in any condition. Adverse effects of trimetazidine are mild and infrequent.
What is the side effect of trimetazidine?
Trimetazidine has a significant side effects profile, with the most common adverse reactions being nausea, vomiting, fatigue, dizziness, and myalgia. The drug can induce or increase parkinsonian symptoms: extrapyramidal rigidity, bradykinesia, and tremor.
What is the generic name of Vastarel?
Zuellig. Trimetazidine hydrochloride. Each modified release film-coated tablet contains Trimetazidine dihydrochloride 35 mg.
What is the function of trimetazidine?
Trimetazidine helps to maintain the energy metabolism of heart muscle cells, protecting them from the effects of reduced oxygen supply. When you take this medication regularly on a long term basis, it can help treat angina by reducing the number of times you get angina.
Why is trimetazidine banned?
Stimulants, together with anabolic androgenic steroids, are regarded as one of the most popular doping substances in sport. On 1 January 2014, a new doping agent – trimetazidine (TMZ) – was added to the WADA Prohibited List. TMZ, a substance prohibited in competition, is classified in the S6b Specified Stimulant Group.
What is the benefit of trimetazidine?
Recent experimental studies have shown that trimetazidine, through selective inhibition of long-chain 3-ketoacyl coenzyme A thiolase activity, reduces FFA oxidation and increases glucose oxidation, which optimizes energy production and protects the ischemic heart [3].
What is the purpose of trimetazidine?
Trimetazidine belongs to the class of medications called fatty acid oxidation inhibitors. It is used to prevent and treat the symptoms of angina (chest pain). Angina is caused by lack of blood supply and oxygen to your heart.
How long should trimetazidine be taken?
In conclusion, treatment with trimetazidine added to the usual treatment for up to 18 months was well tolerated and induced functional improvement in patients with ischaemic dilated cardiomyopathy. Trimetazidine treatment was associated with a significant improvement of LV function and the remodelling process.
What is trimetazidine used for?
Is trimetazidine a stimulant?
What kind of drug is trimetazidine used for?
Trimetazidine is a drug for angina pectoris sold under the brand name Vastarel MR. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France).
Are there any side effects to taking trimetazidine?
Trimetazidine has been treated as a drug with a high safety and tolerability profile. It interacts with monoamine oxidase inhibitors . There is scarce information about trimetazidine’s effect on mortality, cardiovascular events or quality of life.
What is the oral ATC code for trimetazidine?
Clinical data Trade names Vastarel AHFS / Drugs.com International Drug Names Routes of administration Oral ATC code C01EB15 ( WHO)
What is the C Max of trimetazidine 35 mg?
In elderly patients, a 35 mg oral modified release tablet reaches a mean C max of 115 µg/L, with a T max of 2.0-5.0 hours, and a mean AUC 0-12 of 1104 h*µg/L. 3 In young, healthy patients, the same dose reaches a mean C max of 91.2 µg/L, with a T max of 2.0-6.0 hours, and an AUC 0-12h 720 h*µg/L. 3
