What is transitional cell carcinoma of the bladder?
Transitional cell carcinoma (TCC), also called urothelial cell carcinoma (UCC) of the bladder, is the most common primary neoplasm of the urinary bladder, and bladder TCC is the most common tumor of the entire urinary system.
What is the most common histology of bladder cancer?
Pure urothelial carcinoma is the most common histology of bladder cancer, consisting of about 75% of all cases (1). The remaining cases are represented by variant histology (VH), divided into urothelial and non-urothelial subtypes.
Which is the most common site for transitional cell carcinoma of urinary bladder?
Location. The bladder is by far the most common site of transitional cell carcinomas, 50 times more common than TCC of the renal pelvis, and 100 times more common than TCC of the ureter 1.
What are the 3 types of bladder cancer?
The 3 main types of bladder cancer are:
- Urothelial carcinoma. Urothelial carcinoma (or UCC) accounts for about 90% of all bladder cancers.
- Squamous cell carcinoma. Squamous cells develop in the bladder lining in response to irritation and inflammation.
- Adenocarcinoma.
How aggressive is transitional cell carcinoma?
Transitional Cell Carcinoma: An Aggressive Cancer. Transitional cell carcinoma affects the transitional cells of the urinary system and accounts for an overwhelming majority of bladder cancer diagnoses. This cancer may spread rapidly, affecting other organs and becoming life-threatening in some cases.
How is transitional cell carcinoma treated?
Most cases of TCC in the renal pelvis and ureter can be cured if they’re found and diagnosed early enough. Surgery is the standard treatment for this type of cancer. If you need surgery, you may require a nephroureterectomy.
Is transitional cell carcinoma serious?
If it’s high grade, it’s more likely to spread to deeper layers of your bladder, other areas of your body, and your lymph nodes. It’s also likely to come back after treatment. High-grade TCC is the type of bladder cancer that is more likely to be life-threatening.
What is the primary symptom of transitional cell carcinoma?
The symptoms of transitional cell cancer of the kidney are similar to those of other types of kidney cancer. They include blood in the urine and pain in your back, between the lower ribs, and the top of your hip bone. You may also need to pass urine very often or have pain when passing urine.
Is bladder cancer likely to metastasize?
As many as 50% of patients with muscle-invasive bladder cancer may have occult metastases that become clinically apparent within 5 years of initial diagnosis and around 5% will have distant metastasis at the time of initial diagnosis. Most patients with overt metastatic disease die within 2 years despite chemotherapy.
