What is the root cause of multiple myeloma?
The cause of multiple myeloma is unknown. Though there are no known risk factors for multiple myeloma, researchers suggest that genetic abnormalities, such as c-Myc genes or environmental exposures, may play a role. infections.
What type of disease is multiple myeloma?
Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Healthy plasma cells help you fight infections by making antibodies that recognize and attack germs. In multiple myeloma, cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells.
What gene mutation causes multiple myeloma?
Sequencing studies have been used to determine a spectrum of multiple myeloma (MM) mutations. Mutation of certain genes, including KRAS, NRAS, TP53, FAM46C, DIS3 and BRAF, have a high recurrence rate and may play important roles in the pathogenesis, progression and prognosis of MM.
Which pathological state occurs in case of multiple myeloma?
Multiple myeloma (MM) is a clonal plasma cell proliferative disorder characterized by the abnormal increase of monoclonal paraprotein leading to evidence of specific end-organ damage. MM is part of the spectrum of monoclonal gammopathy.
What are the signs of end stage multiple myeloma?
Symptoms of Late-Stage Multiple Myeloma
- Being sick to your stomach.
- Bone pain in your back or ribs.
- Bruising or bleeding easily.
- Feeling very tired.
- Fevers.
- Frequent infections that are hard to treat.
- Losing a lot of weight.
- Not feeling like eating.
How treatable is multiple myeloma?
Multiple myeloma, also known as Kahler’s disease, is a type of blood cancer. There’s no cure, but treatments can slow its spread and sometimes make symptoms go away. A type of white blood cell called a plasma cell makes antibodies that fight infections in your body.
Can you live 10 years with multiple myeloma?
However, some are very skilled and experienced with Multiple Myeloma and have treated many myeloma patients. The data shows these myeloma specialists provide an average life expectancy of 10+ years or more, compared to the average which is at 5.5 years.
Is myeloma a painful death?
Experiencing a Peaceful Passing Accounts of those who have accompanied a loved one as they died from complications of multiple myeloma generally report a relatively calm death in which pain has been effectively managed.
Which is the pathogenesis of multiple myeloma?
Pathogenesis of bone disease in multiple myeloma: from bench to bedside. Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis of the pathogenesis of myeloma-related bone disease is the uncoupling
How is multiple myeloma ( MM ) treated in the US?
ABSTRACT: Multiple myeloma (MM) is a hematologic malignancy of the plasma cell. While its pathogenesis has not been fully elucidated, the treatment of MM has significantly changed over the past 15 years. Today, triple therapy is most often used, with an immunomodulatory drug and/or proteasome inhibitor included in the regimen.
Is there a family history of multiple myeloma?
Family history of multiple myeloma. If a brother, sister or parent has multiple myeloma, you have an increased risk of the disease. Personal history of a monoclonal gammopathy of undetermined significance (MGUS). Every year 1 percent of the people with MGUS in the United States develop multiple myeloma. Complications of multiple myeloma include:
How is osteolytic bone disease related to multiple myeloma?
Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process.
