What is the half-life of factor II?
60 hours
Half-lives of these clotting factors are as follows: Factor II – 60 hours, VII – 4 to 6 hours, IX – 24 hours, and X – 48 to 72 hours. The half-lives of proteins C and S are approximately 8 hours and 30 hours, respectively.
What is the half-life of Factor VII?
approximately 3-6 hours
Description. Factor VII circulates as a single-chain zymogen with molecular weight of about 50,000 daltons. It has the shortest half-life of the procoagulant factors, approximately 3-6 hours.
Which factor has longest half-life?
Depletion of both factor X and factor II (prothrombin) is important for clinical efficacy, and factor II has the longest half-life of the vitamin K-dependent factors (approximately three days) [3,4].
What is the half-life of warfarin?
The half-life of racemic warfarin ranges from 20 to 60 hours. The mean plasma half-life is approximately 40 hours, and the duration of effect is two to five days. 10 Thus, the maximum effect of a dose occurs up to 48 hours after administration, and the effect lingers for the next five days.
Is thrombin a factor 2?
Once the platelets form a temporary plug, blood-clotting factor II (prothrombin) changes to its activated version, factor IIa (thrombin). Factor IIa causes factor I (fibrinogen) to make the stringy protein fibrin. Fibrin wraps itself in and around the temporary clot until it becomes a hard fibrin clot.
Which coagulation factor has shortest life?
Factor VII Deficiency Factor VII has the shortest half-life of all of the clotting factors, estimated to be 6 hours. Factor VII deficiency is a rare autosomal-recessive disorder. The severity of the hemorrhagic diathesis does not correlate with factor VII levels.
What activates factor5?
Factor V is able to bind to activated platelets and is activated by thrombin. On activation, factor V is spliced in two chains (heavy and light chain with molecular masses of 110000 and 73000, respectively) which are noncovalently bound to each other by calcium.
What is factor Xa called?
Factor Xa is the activated form of the coagulation factor X, known eponymously as Stuart-Prower factor. Factor X is an enzyme, a serine endopeptidase, which plays a key role at several stages of the coagulation system.
How long does it take to reverse warfarin?
Table 2
| Type of reversal | Approach |
|---|---|
| Fast (partial) | FFP (immediate replacement of vitamin K dependent coagulation factors—but the correction of the coagulopathy is partial) |
| Prompt (within 4–6 hours) | IV vitamin K |
| Slow (within 24 hours) | Oral vitamin K |
| Ultraslow (over days) | Omit warfarin dose (no vitamin K) |
What are the 12 blood clotting factors?
The following are coagulation factors and their common names:
- Factor I – fibrinogen.
- Factor II – prothrombin.
- Factor III – tissue thromboplastin (tissue factor)
- Factor IV – ionized calcium ( Ca++ )
- Factor V – labile factor or proaccelerin.
- Factor VI – unassigned.
- Factor VII – stable factor or proconvertin.
What is the half life of factor II?
However, since factors II, IX, and X remain active, the patient is not anticoagulated and the INR cannot be trusted. In fact, owing to the 60 h half-life of factor II, the INR does not reflect therapeutic efficacy until after 3–4 days. The early prolongation of the PT can be viewed as a false indication of anticoagulation.
What is the half life of factor XI?
Function. Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form. The plasma half-life of FXI is approximately 52 hours. The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by FXIIa, FXI is a member of the “contact pathway”…
How long is the plasma half life of FXI?
Function. The plasma half-life of FXI is approximately 52 hours. The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by FXIIa, FXI is a member of the “contact pathway” (which includes HMWK, prekallikrein, factor XII, factor XI, and factor IX ).
What is the half life of Coumadin factor VII?
When starting Coumadin therapy, the first coagulation factor to become detectably reduced is factor VII, owing to its short half-life. Consequently, the prothrombin time (PT ) becomes prolonged and the international normalized ratio (INR ) nears the therapeutic range of 2–3.
