Which symptoms is associated with chloramphenicol induced bone marrow suppression?

The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol.

How does chloramphenicol affect bone marrow?

Chloramphenicol produces two types of toxic effect in bone marrow: The first, a common, dose-related, reversible lesion occurs concurrently with chloramphenicol therapy and is characterized by a normally cellular marrow, maturation arrest, vacuolization in erythroid and myeloid cells, reticulocytopenia, and …

Does chloramphenicol cause bone marrow suppression?

Chloramphenicol dose-related bone marrow suppression is observed in virtually all patients who receive the drug. This expected effect of chloramphenicol is due to its ability to reversibly inhibit mitochondrial protein synthesis and ferrochelatase found on the inner membrane of mitochondria.

How does chloramphenicol cause aplastic anemia?

Although chloramphenicol continues to be the leading single cause of drug-induced aplastic anemia, little progress has been made in elucidating the mechanism of its toxic effect. The reversible erythroid depression occurring concurrently with chloramphenicol therapy is a pharmacologic effect.

Do immunosuppressants cause bone marrow suppression?

Bone marrow suppression is a widely recognized side effect of chemotherapeutic/antineoplastic agents, primarily due to the high mitotic rate of this tissue.

What is the most serious form of bone marrow toxicity?

Bone marrow toxicity is most often manifested as suppression, the most frequent side-effect of many cancer chemotherapeutic agents. Rapidly-proliferating bone marrow cells demonstrate unique susceptibility to certain cytotoxic agents compared with their nonproliferating counterparts.

What are examples of chloramphenicol?

chloramphenicol systemic

Anthrax.
Bacterial Infection.
Brucellosis.
Cholera.
Glanders.
Lemierre’s Syndrome.
Meningitis.
Ornithosis.

Is bone marrow suppression serious?

Myelosuppression — also referred to as bone marrow suppression — is a decrease in bone marrow activity resulting in reduced production of blood cells. This condition is a common side effect of chemotherapy. It can range from mild to severe. Severe myelosuppression, called myeloablation, can be fatal.

How long is chloramphenicol in your system?

Chloramphenicol

Clinical data
Metabolism	Liver
Elimination half-life	1.6–3.3 hours
Excretion	Kidney (5–15%), faeces (4%)
Identifiers

What kind of damage does chloramphenicol do to bone marrow?

Chloramphenicol causes two types of bone marrow damage [21]. A frequent, early, dose-related, reversible suppression of the formation of erythrocytes, thrombocytes, and granulocytes (early toxicity).

Are there any side effects to taking chloramphenicol?

Side effects include bone marrow suppression, N/V, fever, rash, urticaria, pruritus, neuropathy, optic neuritis, blurred vision, confusion, headache, mental confusion, gray baby syndrome, thrombocytopenia, aplastic anemia, agranulocytosis, and pseudomembranous colitis. There are no adequate reports or well-controlled studies in human fetuses.

Are there any side effects to chloramphenicol for dogs?

Compounding pharmacies can compound chloramphenicol in a variety of flavors and textures, including pastes and suspensions, that may be easier to administer. Be sure to discuss any side effects with your veterinarian immediately. Chloramphenicol may cause bone marrow suppression (a serious blood disorder) in animals.