How fast does Protazil work?

PROTAZIL quickly reaches therapeutic levels – within 12 hours – without the need for a loading dose at the start of treatment*. If you are concerned about EPM or think your horse might be showing neurological signs, call your veterinarian immediately.

What does levamisole treat in horses?

Levamisole is commercially available as a dewormer for cattle, sheep, goats, and pigs. It also has conventional off-label uses in horses as an immunostimulant and as a medication for treatment of Equine Protozoal Myelitis (EPM).

What is toltrazuril used for in horses?

Toltrazuril For Horses As a treatment for coccidiosis in horses, toltrazuril works by damaging the intracellular developmental stages of coccidia without damaging the cell tissue of the host animal. It is also used as a prophylaxis to prevent coccidian in horses.

What are symptoms of EPM?


  • Ataxia (incoordination), spasticity (stiff, stilted movements), abnormal gait or lameness;
  • Incoordination and weakness, which worsens when going up or down slopes or when head is elevated;

Can you ride horses with EPM?

EPM can cause nerve damage, so a reader wonders if an affected horse can be rehabilitated. For horses that do recover, the improvement is based on the initial severity of the clinical signs (see box). However, not all horses that “improve” according to the clinical scale are able to be safely ridden again.

Can a horse get EPM twice?

A: The short answer is, yes, horses with equine protozoal myeloencephalitis (EPM) can relapse.

What are the side effects of levamisole?


  • Blurred vision.
  • convulsions (seizures)
  • lip smacking or puffing.
  • numbness, tingling, or pain in face, hands, or feet.
  • paranoia (feelings of persecution)
  • puffing of cheeks.
  • rapid or worm-like movements of tongue.
  • trembling or shaking.

Is levamisole safe for horses?

Levamisole should not be administered to horses about to compete because of its ability to metabolise to two central nervous system stimulants, aminorex and pemoline.

Can a horse fully recover from EPM?

If left undiagnosed and untreated, EPM can cause devastating and lasting neurological deficits. The success rate for treated horses is high. Many will improve and a smaller percentage will recover completely, but 10-20% of cases may relapse within two years.

What are signs of EPM in horses?

Learn to Recognize the Symptoms of EPM

  • Ataxia (incoordination), spasticity (stiff, stilted movements), abnormal gait or lameness.
  • Incoordination and weakness which worsens when going up or down slopes or when head is elevated.

What are the first signs of EPM in horses?

Can equine EPM be cured?

EPM has a poor prognosis for getting a horse back to use if parasites occupy the brain and spinal cord (CNS). The damage isn’t reversible.

What’s the difference between decoquinate and oroquin-10?

Both drugs are FDA approved individually for other animals, but not combined for use in horses. Oroquin-10 has started through the FDA review process. Decoquinate has an in-vitro efficacy study completed for EPM, and a safety trial in horses. Oroquin-10 is a ten-day dose of oral paste medication.

What kind of antibody test do you need for oroquin 10?

Oroquin-10 is a ten-day dose of oral paste medication. An antibody test is required before and after the medication. Your vet has to fill out and submit the form, with either a blood sample for the Peptide ELISA, or by sending a positive Multiplex Sn strip.

How long do you give a horse decoquinate?

This new medication combines two older drugs, levamisole and decoquinate. This medication is given for 10 days. EPM can be a complicated and scary disease to horse owners. By working closely with your veterinarian, you can make a plan that best suites you and your horse.

How does levamisole and decoquinate work for horses?

Oroquin-10 was administered to 195 horses so that 0.5 mg/kg decoquinate/ 1mg/kg levamisole in a flavored base for ten days was administered. No adverse events were reported associated with the treatment for 195 horses. Serum from horses obtained pre- treatment and 4-6 weeks post-treatment was available from 146 horses.

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