What does Granulocytopenia mean?

Listen to pronunciation. (GRAN-yoo-loh-SY-toh-PEE-nee-uh) A condition in which there is a lower-than-normal number of granulocytes (a type of white blood cell).

What is the cause of Granulocytopenia?

Causes of agranulocytosis include: Autoimmune disorders, including lupus and rheumatoid arthritis. Bone marrow disease and bone marrow failure disorders like aplastic anemia.

What is the difference between agranulocytosis and Granulocytopenia?

The terms agranulocytosis, granulocytopenia and neutropenia are sometimes used interchangeably. Agranulocytosis implies a more severe deficiency than granulocytopenia. Neutropenia indicates a deficiency of neutrophils (the most common granulocyte cell) only.

What drugs cause Granulocytopenia?

Drugs that can cause agranulocytosis include:

  • antithyroid medications, such as carbimazole and methimazole (Tapazole)
  • anti-inflammatory medications, such as sulfasalazine (Azulfidine), dipyrone (Metamizole), and nonsteroidal anti-inflammatory drugs (NSAIDs)
  • antipsychotics, such as clozapine (Clozaril)

What is the treatment for Granulocytosis?

The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. Antibiotic medications may also be prescribed if there is a positive blood culture for the presence of bacteria or if a significant local infection develops.

What is a normal WBC level?

The normal number of WBCs in the blood is 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 × 109/L). Normal value ranges may vary slightly among different labs. Some labs use different measurements or may test different specimens. Talk to your provider about your test results.

What is Granulocytosis a symptom of?

Granulocytosis occurs when there is an increase in the number of granulocytes (e.g. neutrophils, basophils, or eosinophils) in the blood. Granulocytosis is usually a symptom of an underlying condition or disease, specifically bacterial infections, autoimmune disorders or bone marrow disorders.

How do you know if you have agranulocytosis?

Common symptoms of agranulocytosis include sudden fever, chills, sore throat, and weakness. Other signs of agranulocytosis may include: Rapid heart rate. Rapid breathing.

What does immature Grans mean in a blood test?

What are they? Some automated hematology analyzers report the total number of immature granulocytes (IG) present in your blood sample. Immature granulocytes are white blood cells that have not fully developed before being released from the bone marrow into the blood.

What is an alarming WBC count?

In general, for adults a count of more than 11,000 white blood cells (leukocytes) in a microliter of blood is considered a high white blood cell count.

Is 14.7 WBC high?

The specific number for high white blood cell count varies from one lab testing facility to another, but a general rule of thumb is that a count of more than 10,500 leukocytes in a microliter of blood in adults is generally considered to be high, while 4,500-10,500 is considered within the normal range.

What does high immature granulocytes mean?

A high immature granulocyte count means having more than 2% IGs in your white blood cell count. If your blood test shows up that you have increased white blood cell count and you also have a high immature granulocytes count, then your doctor will run further tests. Sometimes,…

What do low granulocytes mean?

Low levels of granulocytes reduce the body’s ability to fight infections [ 28 ]. Levels above this range are referred to as granulocytosis or neutrophilia. Under normal conditions, the immature granulocyte percentage (IG%) in our blood is less than 1%. Immature granulocyte levels increase rapidly during infections,… Nov 22 2019

What is granulocytes characteristics of?

Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm . They are also called polymorphonuclear leukocytes or polymorphonuclear neutrophils (PMN, PML, or PMNL) because of the varying shapes of the nucleus, which is usually lobed into three segments.

What are immature granulocytes and IG count?

Immature Granulocytes (IGs): What They Are and What IG Count Means. Immature granulocytes are immature white blood cells. The presence of immature granulocytes in blood test results usually means that your body is fighting an infection or inflammation.

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