What is de novo surgery?

The De Novo NT Natural Tissue Graft procedure involves implantation of donor (allograft) viable juvenile cartilage into an area of cartilage damage. The advantage of the De Novo is that a biopsy is not required, and the turnaround time for implantation is much sooner after an initial diagnostic arthroscopy.

What is de novo bone?

Osteopromotive describes a material that promotes the de novo formation of bone. This means that osteoconductive materials will only contribute to new bone growth in an area where there is already vital bone.

Where does Denovo cartilage come from?

De Novo NT is an FDA approved cartilage repair technique. The product is made out of minced cartilage from organ donors under the age of 13. Unlike cartilage in adults, this young tissue has a high proliferative capacity.

What is DeNovo knee surgery?

DeNovo® NT Graft is a particulated juvenile cartilage implant used for the repair of articular cartilage damage. It is intended to provide surgeons with an early-intervention option for articular cartilage repair and cartilage restoration.

What is Osteoconductivity?

Osteoconduction is the ability of bone-forming cells in the grafting area to move across a scaffold and slowly replace it with new bone over time. Osteoconductive materials serve as a scaffold onto which bone cells (osteoblasts and osteoclasts) can attach, migrate, grow and/or divide.

What is arthrex BioCartilage?

BioCartilage® extracellular matrix provides a reproducible, simple and inexpensive method to augment marrow stimulation procedures. BioCartilage matrix is developed from allograft cartilage and contains the extracellular matrix that is native to articular cartilage.

What is the MACI procedure?

Matrix-induced autologous chondrocyte implantation or MACI is a procedure in which a patient’s own cells are used to regrow new cartilage for the knee joint. Because of this, it is a two-part procedure. At first, a cartilage biopsy is performed arthroscopically.

What is a DeNovo graft?

DeNovo NT Graft is a particulated juvenile cartilage implant used for the repair of articular cartilage damage. It is intended to provide surgeons with an early-intervention option for articular cartilage repair.

Is BMP osteoinductive?

The most potent osteoinductive factors are bone morphogenetic protein (BMP). BMPs belong to the TGF-β family [49]. BMP-2 and BMP-7 are being clinically applied for fractures and nonunions [8, 50].

What is the function of hydroxyapatite?

Hydroxyapatite is chemically similar to the mineral component of bone and hard tissues in mammals. It is a bioactive material that will support bone ingrowth and osseointegration. It has been used in orthopedic, dental, and maxillofacial applications and can be replaced with bone formation via osteoconduction.

What is ACI surgery?

Autologous chondrocyte implantation (ACI) is a relatively new, state-of-the-art procedure used to treat isolated full-thickness (down to bone) articular cartilage defects of the knee. It has been approved by the Food and Drug Administration for cartilage defects located at the end of the femur bone (thigh).

What is trial de novo?

In law, the expression trial de novo means a “new trial” by a different tribunal (de novo is a Latin expression meaning “afresh”, “anew”, “beginning again”, hence the literal meaning “new trial”). A trial de novo is usually ordered by an appellate court when the original trial failed to make a determination in a manner dictated by law.

What is de Nova?

De novo may also refer to: De novo, mutation, an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself.

What is de novo review?

De novo judicial review is used in questions of how the law was applied or interpreted. It is a nondeferential standard of review, meaning it does not place weight on the previous court’s finding. A de novo judicial review can reverse the trial court’s decision. “De novo” is a Latin expression meaning “anew,” “from the beginning,” “afresh.”.

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