What is sitagliptin made from?
Sitagliptin Phosphate is the phosphate salt form of sitagliptin, an orally available, competitive, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP-4) with hypoglycemic activity. Sitagliptin may cause an increased risk in the development of pancreatitis.
What is the chemical name for Januvia?
Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate. Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder.
What are the side effects of sitagliptin?
The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with rosiglitazone (Avandia ®).
What is mechanism of action of sitagliptin?
Sitagliptin is a member of the gliptin class of antidiabetic medications. Its mechanism of action is through inhibition of dipeptidyl peptidase-4 (DPP-4), an enzyme that acts to degrade and inactivate glucagon-like peptide-1 (GLP-1).
Is Januvia bad for your kidneys?
No clinical studies have linked the use of Januvia to kidney problems.
Is sitagliptin better than metformin?
Conclusions: In this 24-week monotherapy study, sitagliptin was non-inferior to metformin in improving HbA(1c) in treatment-naïve patients with type 2 diabetes. Although both treatments were generally well tolerated, a lower incidence of gastrointestinal-related adverse experiences was observed with sitagliptin.
What’s another name for Januvia?
Sitagliptin is a prescription drug. It comes as an oral tablet. Sitagliptin oral tablet is available as the brand-name drug Januvia.
What is the best time to take sitagliptin?
You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take sitagliptin before or after a meal.
Why is sitagliptin so expensive?
The lack of generic availability, plus the popularity of the drug, combined with the prevalence of type 2 diabetes in the United States, means that there is a high demand for Januvia and the medication can command high prices.
What is another name for sitagliptin?
Sitagliptin oral tablet is available as the brand-name drug Januvia.
What is the function of sitagliptin?
Sitagliptin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Is Januvia a safe drug?
Overall safety results for Januvia were announced in June 2015 during the American Diabetes Association Scientific Sessions and showed no CV risk among a diverse group of patients taking the drug. A secondary analysis found that the drug did not increase the risk for heart failure among the T2D group.